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Otto Polyakov
Otto Polyakov

[18 ] The Diary 4SD [UPD]


Methods: Adult patients presenting with acute cough were included. GPs recorded co morbidities and clinical findings. Patients filled out a diary for up to 4 weeks on their symptoms, illness perception and related behaviour. The chi-square test was used to compare proportions between groups and the Mann-Whitney U or Kruskal Wallis tests were used to compare means.




[18 ] The Diary 4SD



Results: Three thousand one hundred six patients from 12 European countries were included. Eighty-one per cent (n = 2530) of the patients completed the diary. Patients were feeling unwell for a mean of 9 (SD 8) days prior to consulting. More than half experienced impairment of normal or social activities for at least 1 week and were absent from work/school for a mean of 4 (SD 5) days. On average patients felt recovered 2 weeks after visiting their GP, but 21% (n = 539) of the patients did not feel recovered after 4 weeks. Twenty-seven per cent (n = 691) reported feeling anxious or depressed, and 28% (n = 702) re-consulted their GP at some point during the illness episode. Reported illness duration and days absent from work/school differed between countries and regions (North-West versus South-East), but there was little difference in reported illness course and related behaviour between health care systems (direct access versus gate-keeping).


Hello pilots! Many thanks to all for the activity on the forum and for such a large number of questions. They are many and they are all very different. This is the fourth diary of answers, and we still respond to questions only from the Russian-speaking part of the forum. I will pick from the English side next time. Many of the questions are difficult to answer at this early stage of development. Some issues bring a smile and some make me check to make sure I don't work in a shop with a magic wand from the Harry Potter films.


In this diary entry will still not be any interesting "pictures", but only answers. But we would like to begin to develop our channel on YouTube. We have some very interesting material removed during restoration work on some unique Soviet aircraft period WW2. Come and see. We will make a regular appearance of such materials. Of course, they are not directly related to the work on the project, but it is closely linked to the history of aviation and hence relates to what we are doing for you. Please, use English subtitle.


And of course will be pictures, video and more details about the map and ground equipment. In this diary we publish the fifth part of the test pilot interview, which will be dedicated to the I-153 aircraft.


Good afternoon. Today's diary will be pretty short. This is due to the fact that we're working to complete a new version RoF which will be published soon. And of course, we have many tasks for BoS, so we didn't have much time for questions.


First, I want to respond to the great indignation of the English-speaking community of course. Your accusations are true and we do much more to communicate in Russian. Partly because it very easy for us to speak Russian and partly because the Russian-speaking part of the community is very quick to respond to diary and asks a big number of small and specific questions which we pretty easy to answer. But of course, we understand that we're working with an international group and we should not give rise to the impression that communication with us definitely need to know Russian. We'll try to pay more attention to everything. And Jason has been busy with ROF and other business matters and recently traveled to Russia to meet with us in person so he will also be more active in the English side as the project progresses.


In this diary entry we publish below a video shot by us during our flying experiment in March. In it I recall our visit to the airfield outside Moscow to arrange a dogfight with sporting aircraft. We wanted to understand some of the feelings experienced by pilots in combat and conduct a series of physical experiments. Everything turned out very well. We got a lot of materials which we are using in our work. And at the airfield we decided that we should show some of this stuff to the public. We hope that you will enjoy.


6) Until Offline mode is available, QMB will also require internet connection; 7) Multiplayer mode obviously requires a connection. It's up to you to choose between Online and Offline modes, however the Historical campaign is only available Online, it is the key component of the initial game and it brings you over 70% of the overall new IL-2 Sturmovik experience. Offline features mentioned above will be described in my next diary as well as some notes about mission difficulty and player's progress. =TwrPU-xW2-8&feature=youtu.be You can discuss this news in this thread


Here, we used a novel approach that combined data from a 4-day food diary, integrated into a food tree, together with gut microbiota (shotgun metagenomic) for individuals with IBS (N = 149) and healthy controls (N = 52). Paired microbiota and food-based trees allowed us to detect new associations between subspecies and diet. Combining co-inertia analysis and linear regression models, exhaled gas levels and symptom severity could be predicted from metagenomic and dietary data.


We previously showed that the gut microbiota is associated with symptom severity in IBS and identified a microbial signature for IBS severity that was not associated with the intake of macronutrients [19]. Although considered to be associated with symptom generation in individuals with IBS, details about how the combination of diet and gut microbiota affects symptoms remain unknown [19,20,21]. Therefore, in this study, we investigated the relation between digestive symptoms and extensive datasets of diet and the gut microbiota of individuals with IBS, with a focus on those with severe symptoms, further referred to as severe IBS, making use of a whole-metagenomics sequencing approach and categorized dietary intake based on a 4-day food diary.


We investigated the association of GI symptom severity and patterns with diet and the gut metagenome in 52 healthy controls and 149 individuals with IBS (Table 1). The IBS symptoms were severe, according to the IBS Severity Scoring System (IBS-SSS) [23], in 65 of the 149 individuals with IBS. A 4-day food diary was obtained from 142 subjects (26 healthy controls and 49 individuals with severe IBS). Dietary macronutrients and micronutrients identified as consumed differentially between individuals with IBS and healthy controls or between patients with severe IBS symptoms and other individuals (healthy or non-severe, i.e., mild/moderate IBS symptoms) did not remain significant after correction for multiple testing (Fig. S1 and S2). This suggests that dietary data, aggregated at the micro- and macronutrients levels, differ neither between individuals with IBS and healthy controls nor between IBS patients with different levels of symptom severity. 041b061a72


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